Cerebrospinal Fluid Flow

Circulation of cerebrospinal fluid and interstitial around the central nervous system through brain transports not only those water-like fluids but also any solutes they carry, including nutrients, drugs, metabolic wastes. Passing tissue primarily during sleep, this circulation has implications for neurodegenerative disorders Alzheimer's disease, damage stroke cardiac arrest, flow-related such as hydrocephalus syringomyelia. Recent experimental results reveal several features flow, other aspects are fully understood, its driving mechanisms. We review evidence theoretical modeling roles advection diffusion in transporting solutes. discuss both local, detailed fluid-dynamic models specific components global hydraulic overall network flow paths.